Advances in the development of biomarkers for epilepsy

A Pitkänen, W Löscher, A Vezzani, AJ Becker… - The Lancet …, 2016 - thelancet.com
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …

Translational research in traumatic brain injury

D Laskowitz, G Grant - 2016 - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

[HTML][HTML] Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure

BP Lucke-Wold, L Nguyen, RC Turner, AF Logsdon… - Seizure, 2015 - Elsevier
Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy, C France - Pharmacological reviews, 2022 - Elsevier
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

[HTML][HTML] Epilepsy related to traumatic brain injury

A Pitkänen, R Immonen - Neurotherapeutics, 2014 - Elsevier
Post-traumatic epilepsy accounts for 10–20% of symptomatic epilepsy in the general
population and 5% of all epilepsy. During the last decade, an increasing number of …

[HTML][HTML] Epilepsy after traumatic brain injury

K Ding, PK Gupta, R Diaz-Arrastia - Translational research in …, 2016 - ncbi.nlm.nih.gov
An epileptic seizure is a “transient occurrence of signs and/or symptoms due to abnormal
excessive or synchronous neuronal activity in the brain.” 1 Epilepsy is a disorder of the brain …

[HTML][HTML] Novel approaches to prevent epileptogenesis after traumatic brain injury

CG Dulla, A Pitkänen - Neurotherapeutics, 2021 - Elsevier
Traumatic brain injury (TBI) is defined as an alteration in brain function or other evidence of
brain pathology caused by an external force. When epilepsy develops following TBI, it is …

Management of post‐traumatic epilepsy: An evidence review over the last 5 years and future directions

L Piccenna, G Shears, TJ O'Brien - Epilepsia open, 2017 - Wiley Online Library
Post‐traumatic epilepsy (PTE) is a relatively underappreciated condition that can develop as
a secondary consequence following traumatic brain injury (TBI). The aim of this rapid …

Validation of ICDPIC software injury severity scores using a large regional trauma registry

NH Greene, MA Kernic, MS Vavilala… - Injury …, 2015 - injuryprevention.bmj.com
Background Administrative or quality improvement registries may or may not contain the
elements needed for investigations by trauma researchers. International Classification of …

Genetic influences on patient-oriented outcomes in traumatic brain injury: a living systematic review of non-apolipoprotein E single-nucleotide polymorphisms

FA Zeiler, C McFadyen, VFJ Newcombe… - Journal of …, 2021 - liebertpub.com
There is a growing literature on the impact of genetic variation on outcome in traumatic brain
injury (TBI). Whereas a substantial proportion of these publications have focused on the …