In breast cancer (BC) epithelial cells, the mitogenic action of estradiol is transduced through
binding to two receptors, ERα and ERβ, which act as transcription factors. Anti-estrogens …

To date, three molecular markers (ER, PR, and CYP2D6) have been used in clinical setting
to predict the benefit of the anti-estrogen tamoxifen therapy. Our aim was to validate new …

Recently, a novel class of transcripts, long non-coding RNAs (lncRNAs), is being identified
at a rapid pace. These RNAs have critical roles in diverse biological processes, including …

Context: Fat distribution differs in men and women, but in both sexes, a predominantly
gluteal-femoral compared with abdominal (central) fat distribution is associated with lower …

Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

Introduction Male breast cancer (MBC) is a rare and inadequately characterized disease.
The aim of the present study was to characterize MBC tumors transcriptionally, to classify …

The elucidation of molecular events that confer tamoxifen resistance to estrogen receptor α
(ER) positive breast cancer is of major scientific and therapeutic importance. Here, we report …

The HOX and PBX gene families encode transcription factors that have key roles in
establishing the identity of cells and tissues in early development. Over the last 20 years it …

The HOX genes are a highly conserved group of transcription factors that have key roles in
early development, but which are also highly expressed in most cancers. Many studies have …

Why breast cancers become resistant to tamoxifen despite continued expression of the
estrogen receptor-α (ERα) and what factors are responsible for high HER2 expression in …