Coronavirus proteins as ion channels: current and potential research

C McClenaghan, A Hanson, SJ Lee… - Frontiers in …, 2020 - frontiersin.org
Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to
their exceptional zoonotic potential—a feature arising from their ability to infect a diverse …

Viroporins: structure, function and potential as antiviral targets

C Scott, S Griffin - Journal of General Virology, 2015 - microbiologyresearch.org
The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …

Compounds based on adamantyl-substituted amino acids and peptides as potential antiviral drugs acting as viroporin inhibitors

TM Garaev, TV Grebennikova… - Current …, 2024 - benthamdirect.com
The discussion has revolved around the derivatives of amino acids and peptides containing
carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C …

Increasing the aqueous solubility of N-acyl-substituted amino acid esters as inhibitors of viral replication in vitro using iron (II) ions

TM Garaev, II Yudin, NV Breslav, TV Grebennikova… - Tetrahedron, 2024 - Elsevier
New aromatic and heterocyclic derivatives of N-acylated esters of l-amino acids with
aromatic carboxylic acids are proposed as antiviral low molecular weight agents. To …

[PDF][PDF] Structural biology of coronavirus ion channels

FJ Barrantes - Acta Crystallographica Section D: Structural Biology, 2021 - journals.iucr.org
Viral infection compromises specific organelles of the cell and readdresses its functional
resources to satisfy the needs of the invading body. Around 70% of the coronavirus positive …

Viroporins: Structures and Functions beyond Cell Membrane Permeabilization

JL Nieva, L Carrasco - Viruses, 2015 - mdpi.com
Viroporins represent an interesting group of viral proteins that exhibit two sets of functions.
First, they participate in several viral processes that are necessary for efficient production of …

Ecotoxicology and toxicology of metal-based nanoparticles

P Rath, A Ranjan, A Chauhan, RK Basniwal… - The Role of …, 2022 - Springer
Nanotechnology has emerged as a potential tool to enhance the agriculture, industrial
manufacturing, and healthcare. Nanoparticles (NPs) have unique shape, structure, size, and …

Weak selectivity predicted for modeled bundles of viral channel-forming protein E5 of human papillomavirus-16

DR Mahato, WB Fischer - The Journal of Physical Chemistry B, 2016 - ACS Publications
Protein E5 is a polytopic 83 amino acid membrane protein with three transmembrane
domains (TMDs), encoded by high-risk human papillomavirus-16 (HPV-16). HPV-16 is …

[HTML][HTML] Viral channel forming proteins—How to assemble and depolarize lipid membranes in silico

WB Fischer, MM Kalita, D Heermann - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Viral channel forming proteins (VCPs) have been discovered in the late 70s and are found in
many viruses to date. Usually they are small and have to assemble to form channels which …