Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Atom transfer radical polymerization (ATRP) is one of the most often used controlled radical
polymerization techniques. It employs very small amounts (ppm) of Cu complexes in the …

Immune checkpoint inhibitor (ICI) therapy is effectively employed in treating various
malignancies. However, the response rate is constrained to 5–30%, which is attributed to …

While Si-containing polymers can often be deconstructed using chemical triggers such as
fluoride, acids, and bases, they are resistant to cleavage by mild reagents such as biological …

In the design of delivery strategies for anticancer therapeutics, the controlled release of
intact cargo at the destined tumor and metastasis locations is of particular importance. To …

Background In the tumor microenvironment (TME), tumor-associated macrophages (TAMs)
play a key immunosuppressive role that limits the ability of the immune system to fight …

Activation of the innate immune system counteracts tumor‐induced immunosuppression.
Hence, small molecule‐based toll‐like receptor 7/8 agonists (TLR7/8a), which can modulate …

In the last decades, nanoscale drug delivery systems have gained great attention partly due
to their ability to improve the bioavailability of water insoluble drugs. To this end, the general …

With the recent advances in neoantigen identification, peptide-based cancer vaccines offer
substantial potential in the field of immunotherapy. However, rapid clearance, low …

Immunomodulation is a powerful therapeutic approach that harnesses the body's own
immune system and reprograms it to treat diseases, such as cancer. Innate immunity is key …