The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

Calcium signaling results from a complex interplay between activation and inactivation of
intracellular and extracellular calcium permeable channels. This complexity is obvious from …

Chimeric antigen receptor (CAR) T cells targeting CD19 have achieved breakthroughs in the
treatment of hematological malignancies, such as relapsed/refractory non-Hodgkin …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are intracellular channel proteins
that mediate Ca 2+ release from the endoplasmic reticulum (ER) and are involved in many …

During sepsis, acute lung injury (ALI) results from activation of innate immune cells and
endothelial cells by endotoxins, leading to systemic inflammation through proinflammatory …

Cell-death and-survival decisions are critically controlled by intracellular Ca 2+ homeostasis
and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1, 4, 5-trisphosphate …

There are three isoforms of the inositol 1, 4, 5-trisphosphate receptor (InsP 3 R), each of
which has a distinct effect on Ca 2+ signaling. However, it is not known whether each …

Ca 2+ transfer from endoplasmic reticulum (ER) to mitochondria can trigger apoptotic
pathways by inducing release of mitochondrial pro-apoptotic factors. Three different types of …

Members of the Bcl-2-protein family are key controllers of apoptotic cell death. The family is
divided into antiapoptotic (including Bcl-2 itself, Bcl-xL, Mcl-1, etc.) and proapoptotic …

HIV infection of macrophages is a critically important component of viral pathogenesis and
progression to AIDS. Although the virus follows the same life cycle in macrophages and T …