In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of
a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that …

Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset
excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings …

Microglia are the immunocompetent cells of the central nervous system. In the physiological
setting, their highly motile processes continually survey the local brain parenchyma and …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …

Cadherins mediate cell–cell adhesion but are also involved in intracellular signaling
pathways associated with neuropsychiatric disease. Most of the∼ 100 cadherins that are …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

Autism spectrum disorders (ASD) is a heterogeneous group of neurodevelopmental
disorders characterized by synaptic dysfunction and defects in dendritic spine morphology …

The small size of dendritic spines belies the elaborate role they play in excitatory synaptic
transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is …