The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

In addition to their classical roles as detergents to aid in the process of digestion, bile acids
have been identified as important signaling molecules that function through various nuclear …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

In liver and intestine, transporters play a critical role in maintaining the enterohepatic
circulation and bile acid homeostasis. Over the past two decades, there has been significant …

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver
into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood …

ATP binding cassette (ABC) drug transporters play an important role in cancer drug
resistance, protection against xenobiotics, and in general in the passage of drugs through …