There is a pressing need to capture and track subtle cognitive change at the preclinical
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …

The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

Human episodic memory critically depends on subregions of the medial temporal lobe,
which are part of functional brain systems such as the anterior-temporal and the posterior …

Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …

Alzheimer's disease researchers have been intrigued by the selective regional vulnerability
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …

Recent evidence challenges the widely held view that the hippocampus is specialized for
episodic memory, by demonstrating that it also underpins the integration of information …

Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC)
in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve …

In early Alzheimer's disease (AD) β-amyloid (Aβ) deposits throughout association cortex and
tau appears in the entorhinal cortex (EC). Why these initially appear in disparate locations is …

During early ontogeny, the rapid and cumulative acquisition of world knowledge contrasts
with slower improvements in the ability to lay down detailed and long-lasting episodic …