Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …

Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is
symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory …

The prevalence of diabetes is growing worldwide with an increasing morbidity and mortality
associated with the development of diabetes complications. Free radical production is a …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

It is now accepted that nutrient abundance in the blood, especially glucose, leads to the
generation of reactive oxygen species (ROS), ultimately leading to increased oxidative …

Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to
acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Cytochromes P450 are responsible for metabolism of most xenobiotics and are required for
the efficient elimination of foreign chemicals from the body. Paradoxically, these enzymes …

The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of …

In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in
North Carolina were found to be contaminated with the industrial solvents trichloroethylene …