Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

Unlike acute myocardial infarction with reperfusion, in which infarct size is the end point
reflecting irreversible injury, myocardial stunning and hibernation result from reversible …

Heusch, Gerd. Hibernating Myocardium. Physiol. Rev. 78: 1055–1085, 1998.—Decreased
myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of …

The pathophysiology of myocardial hibernation is characterized as a situation of reduced
regional contractile function distal to a coronary artery stenosis that recovers after removal of …

1. Introduction duction, but that the impaired flow also results in impaired removal of
metabolic waste products. In the large majority Although myocardial ischaemia has been …

To improve human health, scientific discoveries must be translated into practical
applications. Inherent in the development of these technologies is the role of preclinical …

Myocardial ischemia occurs for a mismatch between blood flow and metabolic requirements,
when the rate of oxygen and metabolic substrates delivery to the myocardium is insufficient …

Distal to a chronic coronary artery stenosis, structural remodeling of the microvasculature
occurs. The microvascular functional changes distal to the stenosis have not been studied in …

Background—Viable, chronically dysfunctional myocardium can have normal or reduced
resting flow. We previously produced hibernating myocardium with reduced resting flow in …

Regions of hibernating myocardium are common in patients with ischemic cardiomyopathy
and have a negative impact on survival rates in the absence of coronary revascularization …