Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

Much effort has been expended in the search for inhibitors of signalling molecules that may
prove to be important therapeutically in cancer. The epidermal growth factor receptor …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that
exhibits extremely high levels of genetic complexity and yet a relatively uniform …

The tumour stroma is believed to contribute to some of the most malignant characteristics of
epithelial tumours. However, signalling between stromal and tumour cells is complex and …

Trophoblast research over the past decades has underlined the striking similarities between
the proliferative, migratory and invasive properties of placental cells and those of cancer …

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma.
The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are …

The regulation of plasminogen activation involves genes for two plasminogen activators
(tissue type and urokinase type), two specific inhibitors (type 1 and type 2), and a membrane …

Abstract Interleukin 8 (IL-8) is mitogenic and chemotactic for endothelial cells. Within a
neoplasm, IL-8 is secreted by inflammatory and neoplastic cells. The highly metastatic PC …