The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Extracellular vesicles through the blood–brain barrier: A review

HM Ramos-Zaldívar, I Polakovicova… - Fluids and Barriers of …, 2022 - Springer
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a
lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in …

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

DE Murphy, OG de Jong, M Brouwer… - … & molecular medicine, 2019 - nature.com
Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …

Extracellular membrane vesicles in the three domains of life and beyond

S Gill, R Catchpole, P Forterre - FEMS microbiology reviews, 2019 - academic.oup.com
Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

D Rufino-Ramos, PR Albuquerque, V Carmona… - Journal of Controlled …, 2017 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all
cells, including brain cells. EVs are a major term that includes apoptotic bodies …

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

C Villarroya-Beltri, F Baixauli, M Mittelbrunn… - Nature …, 2016 - nature.com
Exosomes are vesicles secreted to the extracellular environment through fusion with the
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …

Routes and mechanisms of extracellular vesicle uptake

LA Mulcahy, RC Pink, DRF Carter - Journal of extracellular …, 2014 - Taylor & Francis
Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

HC Christianson, KJ Svensson… - Proceedings of the …, 2013 - National Acad Sciences
Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic
acids has recently been implicated in the development of cancer and other pathological …

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

M Record, K Carayon, M Poirot… - Biochimica et Biophysica …, 2014 - Elsevier
Exosomes are nanovesicles that have emerged as a new intercellular communication
system between an intracellular compartment of a donor cell towards the periphery or an …