Abstract Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking,
including those of the upper aerodigestive tract, the liver, the colorectum and the breast …

Oral cancer incidence rates rose dramatically during the twentieth century in the United
States and Europe, especially among individuals under the age of 60 years. Although …

Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …

Background Alcohol is a well-established risk factor for head and neck cancer (HNC). This
study aims to explore the effect of alcohol intensity and duration, as joint continuous …

Background: The magnitude of risk conferred by the interaction between tobacco and
alcohol use on the risk of head and neck cancers is not clear because studies have used …

Epigenetic control of gene transcription is critical for normal human development and
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …

Background: Increasing incidence of head and neck cancer (HNC) in young adults has been
reported. We aimed to compare the role of major risk factors and family history of cancer in …

Recent work has begun to explore the instrumental role that small noncoding RNA species,
particularly microRNAs (miRNA), have both in classifying human tumors and in directing …

Objective Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly
onerous prognosis, encouraging further research on factors that might modify disease …

Background: Head and neck squamous cell carcinoma (HNSCC) is commonly associated
with tobacco and alcohol exposures, although dietary factors, particularly folate, and human …