The physiology of venous and tissue CO 2 monitoring has a long and well-established
physiological background, leading to the technological development of different tissue …

Rationale: Early post injury mitigation strategies in ARDS are in short supply. Treatments
with allogeneic stromal cells are administered after ARDS develops, require specialized …

Background Despite much evidence supporting the monitoring of the divergence of
transcutaneous partial pressure of carbon dioxide (tcPCO 2) from arterial partial pressure …

Massive blood loss, a common pathological complication in the clinic, is often accompanied
by altered gut integrity and intestinal wall damage. Little is known to what extent the gut …

Purpose: End-tidal CO 2 (eTCO 2) can be used to estimate the arterial CO 2 (PaCO 2) under
steady-state conditions, but that relationship deteriorates during hemodynamic or respiratory …

Background: Inadvertent hyperventilation is associated with poor outcomes from traumatic
brain injury (TBI). Hypocapnic cerebral vasoconstriction is well described and causes an …

Cardiothoracic trauma represents a significant challenge for the anesthesiologist, and little
robust investigational evidence exists to guide management decisions. Injury patterns are …

Severe sepsis and septic shock remain significant international health burdens with high
mortalities and financial implications. Rapid identification of the septic patient is imperative …

The July 2016 issue of Shock provides two excellent clinical review articles, four clinical
research reports, as well as seven basic science reports. The first review article by Smith et …