Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy
complications and adverse perinatal outcomes. GDM often reoccurs and is associated with …

Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Obesity is commonly accompanied by chronic tissue inflammation and leads to insulin
resistance. Aerobic exercise is an essential treatment for insulin resistance and has anti …

Most of the single-nucleotide polymorphisms (SNPs) associated with insulin resistance (IR)-
relevant phenotypes by genome-wide association studies (GWASs) are located in …

Key points Exercising at different times of day elicits different effects on exercise
performance and metabolic health. However, the specific signals driving the observed time …

Background The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in
adult muscle satellite cells (SCs) within hours following muscle damage and is required for …

Skeletal muscle is the most abundant component of the mature mammalian phenotype.
Designed to generate contractile force and movement, skeletal muscle is crucial for …

Skeletal muscle is a dynamic tissue the size of which can be remodeled through the
concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional …

Aims/hypothesis Genome-wide association studies (GWAS) have identified hundreds of type
2 diabetes loci, with the vast majority of signals located in non-coding regions; as a …