Recent advances and perspectives on production of value-added organic acids through metabolic engineering

H Liu, Y Jin, R Zhang, Y Ning, Y Yu, P Xu, L Deng… - Biotechnology …, 2023 - Elsevier
Organic acids are important consumable materials with a wide range of applications in the
food, biopolymer and chemical industries. The global consumer organic acids market is …

Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects

X Yin, J Li, H Shin, G Du, L Liu, J Chen - Biotechnology advances, 2015 - Elsevier
Organic acids, which are chemically synthesized, are also natural intermediates in the
metabolic pathways of microorganisms, among which the tricarboxylic acid (TCA) cycle is …

Microbial cell factories based on filamentous bacteria, yeasts, and fungi

Q Ding, C Ye - Microbial Cell Factories, 2023 - Springer
Background Advanced DNA synthesis, biosensor assembly, and genetic circuit
development in synthetic biology and metabolic engineering have reinforced the application …

Microbial production of specialty organic acids from renewable and waste materials

S Alonso, M Rendueles, M Díaz - Critical reviews in biotechnology, 2015 - Taylor & Francis
Microbial production of organic acids has become a fast-moving field due to the increasing
role of these compounds as platform chemicals. In recent years, the portfolio of specialty …

Engineering synergetic CO2-fixing pathways for malate production

G Hu, J Zhou, X Chen, Y Qian, C Gao, L Guo, P Xu… - Metabolic …, 2018 - Elsevier
Increasing the microbial CO 2-fixing efficiency often requires supplying sufficient ATP and
redirecting carbon flux for the production of metabolites. However, addressing these two …

Anaerobic fermentation for production of carboxylic acids as bulk chemicals from renewable biomass

J Wang, M Lin, M Xu, ST Yang - Anaerobes in biotechnology, 2016 - Springer
Biomass represents an abundant carbon-neutral renewable resource which can be
converted to bulk chemicals to replace petrochemicals. Carboxylic acids have wide …

Rewiring the reductive tricarboxylic acid pathway and L-malate transport pathway of Aspergillus oryzae for overproduction of L-malate

J Liu, Z Xie, H Shin, J Li, G Du, J Chen, L Liu - Journal of Biotechnology, 2017 - Elsevier
Aspergillus oryzae finds wide application in the food, feed, and wine industries, and is an
excellent cell factory platform for production of organic acids. In this work, we achieved the …

Current advance in biological production of short-chain organic acid

L Sun, M Gong, X Lv, Z Huang, Y Gu, J Li, G Du… - Applied Microbiology …, 2020 - Springer
As natural metabolites, organic acids have been widely applied in food, pharmaceutical, and
bio-based materials industries. Particularly, the short-chain organic acids, including C2, C3 …

Protein and metabolic engineering for the production of organic acids

J Liu, J Li, H Shin, L Liu, G Du, J Chen - Bioresource Technology, 2017 - Elsevier
Organic acids are natural metabolites of living organisms. They have been widely applied in
the food, pharmaceutical, and bio-based materials industries. In recent years …

Bioproduction of fumaric acid: An insight into microbial strain improvement strategies

J Sebastian, K Hegde, P Kumar, T Rouissi… - Critical reviews in …, 2019 - Taylor & Francis
Fumaric acid (FA), a metabolic intermediate, has been identified as an important
carbohydrate derived platform chemical. Currently, it is commercially sourced from …