[HTML][HTML] Natural products in drug discovery: advances and opportunities

AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer's and Parkinson's diseases

S Saha, B Buttari, E Profumo, P Tucci… - Frontiers in cellular …, 2022 - frontiersin.org
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …

Glucosinolates from cruciferous vegetables and their potential role in chronic disease: Investigating the preclinical and clinical evidence

EL Connolly, M Sim, N Travica, W Marx… - Frontiers in …, 2021 - frontiersin.org
An increasing body of evidence highlights the strong potential for a diet rich in fruit and
vegetables to delay, and often prevent, the onset of chronic diseases, including …

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease

T Jiang, Q Sun, S Chen - Progress in neurobiology, 2016 - Elsevier
Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

I Buendia, P Michalska, E Navarro, I Gameiro… - Pharmacology & …, 2016 - Elsevier
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Drug delivery of natural products through nanocarriers for effective breast cancer therapy: A comprehensive review of literature

KM Yap, M Sekar, S Fuloria, YS Wu… - International Journal …, 2021 - Taylor & Francis
Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a
global health issue affecting millions of women annually. Poor prognosis in BC patients is …

[HTML][HTML] The multifaceted role of Nrf2 in mitochondrial function

KM Holmström, RV Kostov… - Current opinion in …, 2016 - Elsevier
The transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the master
regulator of the cellular redox homeostasis. Nrf2 target genes comprise of a large network of …

Efficacy of sulforaphane in neurodegenerative diseases

G Schepici, P Bramanti, E Mazzon - International journal of molecular …, 2020 - mdpi.com
Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it
was also found in seeds and mature plants, SFN is mainly present in sprouts of many …

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases

RM Kamal, AF Abdull Razis, NS Mohd Sukri… - Molecules, 2022 - mdpi.com
Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that
affect the nervous system and heart, all of which are vital to the human body. To maintain …