Ion channels are involved in a variety of fundamental physiological processes, and their
malfunction causes numerous human diseases. Therefore, ion channels represent a class of …

Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …

The two-pore potassium channel, TRESK has been implicated in nociception and pain
disorders. We have for the first time investigated TRESK function in human nociceptive …

Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …

Recent evidence points to a pivotal contribution of a variety of different potassium channels,
including two-pore domain potassium (K2P) channels, in chronic pain processing …

Abstract Withaferin A (WFA), a C 5, C 6-epoxy steroidal lactone isolated from the medicinal
plant Withania somnifera (L.) Dunal, inhibits growth of tumor cells in different cancer types …

There is a long-sought need for superior pharmacotherapy of pain syndromes. Although
universal enhancement of K+ channel function in the periphery can decrease nociceptive …

Pain is the most common reason for patients seeking medical care resulting in an estimated
world market for analgesics of more than USD 50 billion. Pain is a highly complex …

Two-pore domain K+ (K2P) channels generate K+ leak current, which serves a vital role in
controlling and modulating neuronal excitability. This diverse family of K+ channels exhibit …

TWIK-related spinal cord K+ channel (TRESK) is the gene product of KCNK18, the last
discovered leak potassium K 2P channel gene. Under resting conditions, TRESK is …