Impurity retention and pharmaceutical solid solutions: visualizing the effect of impurities on dissolution and growth using dyed crystals
A Nong, C Schleper, A Martin, M Paolello… - …, 2024 - pubs.rsc.org
Pharmaceutical solid solutions are gaining increased interest as alternatives to salts and co-
crystals for the enhancement of drug solubility and dissolution kinetics. Industrially, they are …
crystals for the enhancement of drug solubility and dissolution kinetics. Industrially, they are …
Impurity-induced acceleration of polymorphic conversion via crystalline solid solutions and the T–X phase diagrams of salicylic acid and 3-hydroxybenzoic acid
Two T–X binary phase diagrams have been constructed between salicylic acid (SA) and two
monotropic polymorphs of the isomer 3-hydroxybenzoic acid (3HBA). Crystalline solid …
monotropic polymorphs of the isomer 3-hydroxybenzoic acid (3HBA). Crystalline solid …
Thermodynamic Stability Transitions and Coexistence of Two Polymorphs via Crystalline Solid Solutions: The TX Phase Diagram of Salicylic Acid and 2, 3 …
SS Mohajerani, M Paolello, B Linehan… - Crystal Growth & …, 2024 - ACS Publications
The thermodynamically stable phases of salicylic acid (SA) and 2, 3-dihydroxybenzoic acid
(23DHBA) have been determined experimentally in a TX phase diagram from 25° C to …
(23DHBA) have been determined experimentally in a TX phase diagram from 25° C to …
Dirty Nucleation of Salicylic Acid
FL Nordstrom, Y Wang - Crystal Growth & Design, 2024 - ACS Publications
Nucleation studies have been conducted on salicylic acid in the presence of solid-state
miscible impurities. Crystallizations were carried out at different seed loads and …
miscible impurities. Crystallizations were carried out at different seed loads and …