Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their …

Over the last decade remarkable progress has been made in enhancing the efficacy of CAR
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …

Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling
is essential for establishing diverse cellular identities, but how the epigenetic program in …

Immune activated T lymphocytes modulate the activity of key metabolic pathways to support
the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell …

After antigen encounter by CD4+ T cells, polarizing cytokines induce the expression of
master regulators that control differentiation. Inactivation of the histone methyltransferase …

Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …

During the last decade, advances in sequencing technologies allowed production of a
wealth of information on epigenetic modifications in T cells. Epigenome maps, in …