The dynamic signal encoding paradigm suggests that information flows from the
extracellular environment into specific signaling patterns (encoding) that are then read by …

We have presented 'trans-omics', a discipline that mechanistically connects multiple omic
layers. The relationships between molecules of distinct omic layers are governed by reaction …

Tumor development is driven by complex combinations of biological elements. Recent
advances suggest that molecularly distinct subtypes of breast cancers may respond …

The desire to harness nature's capability of precise gene expression regulation has
motivated the pursuit of synthetic gene circuits. However, designing and building novel …

Eukaryotic transcription factors (TF s) coordinate different upstream signals to regulate the
expression of their target genes. To unveil this regulatory network in B‐cell receptor …

We describe a microfluidic cell culture and monitoring system that temporally controls
molecule concentrations around cells cultured in a small space. The simple system consists …

Aiming at the problem that intelligent algorithm can not accurately quantify the mathematical
model of each subsystem in the process of multi-variable system identification combined …

Abstract The rise of Big Data has enabled sophisticated analysis of the human genome in
unprecedented detail. Large datasets are now collected as a matter of routine, and their …