Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack
U Ghani - European journal of medicinal chemistry, 2015 - Elsevier
Abstract Treatment of diabetes mellitus by oral α-glucosidase inhibitors is currently confined
to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects …
to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects …
Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious
public health threat worldwide. It is a severe endocrine metabolic disorder that has the ability …
public health threat worldwide. It is a severe endocrine metabolic disorder that has the ability …
Synthetic routes to chiral nonracemic and racemic dihydro-and tetrahydrothiophenes
S Benetti, C De Risi, GP Pollini, V Zanirato - Chemical Reviews, 2012 - ACS Publications
Natural and man-made organosulfur compounds play important roles in biological and
medicinal chemistry. 1 Among the various classes of organic sulfur compounds, dihydro-and …
medicinal chemistry. 1 Among the various classes of organic sulfur compounds, dihydro-and …
Naturally occurring sulfonium-ion glucosidase inhibitors and their derivatives: a promising class of potential antidiabetic agents
S Mohan, R Eskandari, BM Pinto - Accounts of chemical research, 2014 - ACS Publications
In humans, four different enzymes mediate the digestion of ingested carbohydrates. First
salivary and pancreatic α-amylases, the two endoacting retaining glucosidases, break down …
salivary and pancreatic α-amylases, the two endoacting retaining glucosidases, break down …
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors
W Xie, G Tanabe, J Akaki, T Morikawa… - Bioorganic & medicinal …, 2011 - Elsevier
Two hitherto missing members of sulfonium salts family in Salacia genus plants as a new
class of α-glucosidase inhibitors, neoponkoranol (7) and neosalaprinol (8), were isolated …
class of α-glucosidase inhibitors, neoponkoranol (7) and neosalaprinol (8), were isolated …
Synthetic access to thiolane-based therapeutics and biological activity studies
Secondary metabolites isolated from bioactive extracts of natural sources iteratively pioneer
the research in drug discovery. Modern medicine is often inspired by bioactive natural …
the research in drug discovery. Modern medicine is often inspired by bioactive natural …
In silico design, synthesis and evaluation of 3′-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine “ …
G Tanabe, S Nakamura, N Tsutsui… - Chemical …, 2012 - pubs.rsc.org
In silico design, synthesis and evaluation of 3′- O -benzylated analogs of salacinol, a potent
α-glucosidase inhibitor isolated from an Ayurvedic tra ... - Chemical Communications (RSC …
α-glucosidase inhibitor isolated from an Ayurvedic tra ... - Chemical Communications (RSC …
Biological evaluation of 3′-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3′ position in the side chain on the α-glucosidase inhibitory …
G Tanabe, T Otani, W Cong, T Minematsu… - Bioorganic & medicinal …, 2011 - Elsevier
Four analogs with 3′-O-alkyl groups (9a: CH3, 9b: C2H5, 9c: C13H27 or 9d: CH2Ph)
instead of the 3′-O-sulfate anion in salacinol (1), a naturally occurring potent α-glucosidase …
instead of the 3′-O-sulfate anion in salacinol (1), a naturally occurring potent α-glucosidase …
Hypoxia-activated, small-molecule-induced gene expression
SL Collins, J Saha, LC Bouchez… - ACS Chemical …, 2018 - ACS Publications
Hypoxia, a condition of reduced oxygen, occurs in a wide variety of biological contexts,
including solid tumors and bacterial biofilms, which are relevant to human health …
including solid tumors and bacterial biofilms, which are relevant to human health …
Probing the intestinal α‐glucosidase enzyme specificities of starch‐digesting maltase‐glucoamylase and sucrase‐isomaltase: synthesis and inhibitory properties of 3 …
R Eskandari, K Jones… - … A European Journal, 2011 - Wiley Online Library
The synthesis and glucosidase inhibitory activities of two C‐3′‐and C‐5′‐β‐maltose‐
extended analogues of the naturally occurring sulfonium‐ion inhibitor, de‐O‐sulfonated …
extended analogues of the naturally occurring sulfonium‐ion inhibitor, de‐O‐sulfonated …