Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …

Background Despite well‐recognized differences in the atherosclerotic cardiovascular
disease risk between men and women, sex differences in risk factors and sex‐specific …

Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions in
lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical …

Background: Lipid metabolism plays an essential role in nervous system development.
Cholesterol deficiency leads to a variety of neurodevelopmental disorders, such as autism …

The polygenic risk score (PRS) is calculated as the weighted sum of an individual's
genotypes and their estimated effect sizes, which is often used to estimate an individual's …

Cardiovascular diseases (CVD) are the leading cause of death worldwide for both men and
women, but their prevalence and burden show marked sex differences. The existing …

Background Previous studies have yielded conflicting findings regarding the association
between circulating lipids and lipid-lowering drugs with urinary stones, and the causal …

Objective The aim of this study was to investigate when the association between childhood
obesity and adult cardiometabolic disorders starts to be operative. Methods The study cohort …