Plants are a rich source of new antiviral, pharmacologically active agents. The naturally
occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …

The viral infection caused by SARS-CoV-2 has increased the mortality rate and engaged
several adverse effects on the affected individuals. Currently available antiviral drugs have …

Interferon-gamma (IFNG) is a pleiotropic cytokine that modulates both innate and adaptive
immune networks; it is the most potent activator of macrophages and a signature cytokine of …

During viral infection the first challenge that viruses have to overcome is gaining access to
the intracellular compartment. The infection process starts when the virus contacts the …

Apolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and
cholesterol homeostasis. In addition to being a well-known genetic determinant of both …

Hepatitis C infection is the leading cause of liver diseases worldwide and a major health
concern that affects an estimated 3% of the global population. Novel therapies available …