Neuroprotective effect of HIF prolyl hydroxylase inhibition in an in vitro hypoxia model

M Savyuk, M Krivonosov, T Mishchenko, I Gazaryan… - Antioxidants, 2020 - mdpi.com
A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor
(HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in …

Novel algorithm of network calcium dynamics analysis for studying the role of astrocytes in neuronal activity in alzheimer's disease models

EV Mitroshina, AM Pakhomov, MI Krivonosov… - International Journal of …, 2022 - mdpi.com
Accumulated experimental data strongly suggest that astrocytes play an important role in the
pathogenesis of neurodegeneration, including Alzheimer's disease (AD). The effect of …

Signatures of the consolidated response of astrocytes to ischemic factors in vitro

EV Mitroshina, MI Krivonosov, DE Burmistrov… - International Journal of …, 2020 - mdpi.com
Whether and under what conditions astrocytes can mount a collective network response has
recently become one of the central questions in neurobiology. Here, we address this …

Unravelling the Collective Calcium Dynamics of Physiologically Aged Astrocytes under a Hypoxic State In Vitro

EV Mitroshina, MI Krivonosov, AM Pakhomov… - International Journal of …, 2023 - mdpi.com
Astrocytes serve many functions in the brain related to maintaining nerve tissue homeostasis
and regulating neuronal function, including synaptic transmission. It is assumed that …

Double-edged sword of vitamin D3 effects on primary neuronal cultures in hypoxic states

M Loginova, T Mishchenko, M Savyuk… - International Journal of …, 2021 - mdpi.com
The use of vitamin D3 along with traditional therapy opens up new prospects for increasing
the adaptive capacity of nerve cells to the effects of a wide range of stress factors, including …

Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra (aryl) porphyrazines

MO Savyuk, VD Turubanova, TA Mishchenko… - Cells, 2022 - mdpi.com
The current efforts in photodynamic therapy (PDT) of brain cancer are focused on the
development of novel photosensitizers with improved photodynamic properties, targeted …

Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network

Z Li, Y Tsybina, S Gordleeva, A Zaikin - Mathematics, 2022 - mdpi.com
Working memory refers to the capability of the nervous system to selectively retain short-term
memories in an active state. The long-standing viewpoint is that neurons play an …

Unravelling Contributions of Astrocytic Connexin 43 to the Functional Activity of Brain Neuron–Glial Networks under Hypoxic State In Vitro

TA Mishchenko, RS Yarkov, MO Saviuk, MI Krivonosov… - Membranes, 2022 - mdpi.com
Brain hypoxia remains an Achilles' heel for public health that must be urgently addressed.
Hypoxic damage affects both neurons and glial cells, particularly astrocytes, which are in …

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

X Mi, ABY Chen, D Duarte, E Carey, CR Taylor… - …, 2024 - pmc.ncbi.nlm.nih.gov
Optical recording of intricate molecular dynamics is becoming an indispensable technique
for biological studies, accelerated by the development of new or improved biosensors and …

Modelling and revealing intelligence in complex biological systems: a regard from genetic circuits to neuronal networks

Z Li - 2024 - discovery.ucl.ac.uk
Numerous real-world phenomena and challenges require a new way of thinking from a
systems perspective and this new approach is broadly called complex sys-tems. Instead of …