Background For complex patients in the intensive care unit or in the operating room, many
questions regarding their haemodynamic management cannot be answered with simple …

The clinical determination of the intravascular volume can be extremely difficult in critically ill
and injured patients as well as those undergoing major surgery. This is problematic because …

From the Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical
School, Norfolk, VA. Address reprint requests to Paul E. Marik, MD, FCCM, FCCP, Eastern …

Objective: Acute respiratory distress syndrome might be associated with an increase in
extravascular lung water index and pulmonary vascular permeability index, which can be …

Extravascular lung water (EVLW) is the amount of fluid that is accumulated in the interstitial
and alveolar spaces. In lung oedema, EVLW increases either because of increased lung …

Rationale: Experimental data suggest that manipulation of alveolar fluid clearance with β-
agonists can accelerate the resolution of alveolar edema and improve survival. Objective: To …

Advanced haemodynamic monitoring remains a cornerstone in the management of the
critically ill. While rates of pulmonary artery catheter use have been declining, there has …

Background The prognostic value of extravascular lung water indices (EVLWI) has been
widely investigated, which is determined by lung ultrasound B-lines. However, the clinical …

Background Protective ventilation strategy has been shown to reduce ventilator-induced
lung injury in patients with ARDS. In this study, we questioned whether protective ventilatory …

Rationale: There is no effective pharmacological treatment for acute lung injury (ALI). Statins
are a potential new therapy because they modify many of the underlying processes …