The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Highlights•Voltage-gated ion channels participate in memory formation.•Intrinsic plasticity is
not only global but it might be also local.•Intrinsic plasticity shares common learning rules …

Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …

Cerebellar dysfunction relates to various psychiatric disorders, including autism spectrum
and depressive disorders. However, the physiological aspect is less advanced. Here, we …

For many decades, the predominant view in the cerebellar field has been that the
olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex …

A puzzling observation in the study of autism spectrum disorder (ASD) in mouse models has
been the deregulation of long-term synaptic depression (LTD), a form of experience …

Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such …

The parallel fiber-Purkinje cell (PF-PC) synapse represents the point of maximal signal
divergence in the cerebellar cortex with an estimated number of about 60 billion synaptic …

Control of Ca 2+ flux between the cytosol and intracellular Ca 2+ stores is essential for
maintaining normal cellular function. It has been well established in both neuronal and non …

The cerebellum governs motor coordination and motor learning. Infection with external
microorganisms, such as viruses, bacteria, and fungi, induces the release and production of …