Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

ATG4B stimulates autophagy by promoting autophagosome formation through reversible
modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase …

Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small
intestine. In normal conditions, they function as the cornerstones of intestinal health by …

Autophagy has been implicated in the progression and chemoresistance of various cancers.
In this study, we have shown that osteosarcoma Saos-2 cells lacking ATG4B, a cysteine …

Eukaryotes initiate autophagy when facing environmental changes such as a lack of
external nutrients. However, the mechanisms of autophagy initiation are still not fully …

The intestinal mucosa is a site of multiple stressors and forms the barrier between the
internal and external environment. In the intestine, a complex interplay between the …