Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Kléber, André G., and Yoram Rudy. Basic Mechanisms of Cardiac Impulse Propagation and
Associated Arrhythmias. Physiol Rev 84: 431–488, 2004; 10.1152/physrev. 00025.2003 …

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

Gap junctions are made up of connexin proteins, which comprise a multigene family in
mammals. Targeted mutagenesis of connexin43 (Cx43), one of the most prevalent connexin …

Adjacent cells share ions, second messengers and small metabotes through intercellular
channels which are present in gap junctions. This type of intercellular communication …

Background Slow, nonuniform conduction caused by abnormal gap-junctional coupling of
infarct-related myocardium is thought to be a component of the arrhythmogenic substrate …

DNAs coding for seven murine connexins (Cx)(Cx26, Cx31, Cx32, Cx37, Cx40, Cx43, and
Cx45) are functionally expressed in human HeLa cells that were deficient in gap junctional …

Gender-based differences found in cardiovascular diseases raise the possibility that
estrogen may have direct effects on cardiac tissue. Therefore we investigated whether …

Congestive heart failure is associated with a high risk of life-threatening ventricular re-
entrant arrhythmias. Down-regulation of the principal gap-junctional protein of the ventricular …

Gap junctions, assembled from connexins, form the cell-to-cell pathways for propagation of
the precisely orchestrated patterns of current flow that govern the regular rhythm of the …