Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Mechanisms of secretion and spreading of pathological tau protein
CA Brunello, M Merezhko, RL Uronen… - Cellular and Molecular …, 2020 - Springer
Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
A reference human induced pluripotent stem cell line for large-scale collaborative studies
CB Pantazis, A Yang, E Lara, JA McDonough… - Cell stem cell, 2022 - cell.com
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …
development and disease, but the considerable phenotypic variation between lines makes it …
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega… - Neuron, 2018 - cell.com
We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …
kinetics of multiple isoforms and fragments of tau in the human central nervous system …
Neuronal activity enhances tau propagation and tau pathology in vivo
Tau protein can transfer between neurons transneuronally and trans-synaptically, which is
thought to explain the progressive spread of tauopathy observed in the brain of patients with …
thought to explain the progressive spread of tauopathy observed in the brain of patients with …
[HTML][HTML] ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
Frontotemporal dementia (FTD) because of MAPT mutation causes pathological
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …
2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …
G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
R Simone, R Balendra, TG Moens, E Preza… - EMBO molecular …, 2018 - embopress.org
Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are …
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are …
Hallmarks of Alzheimer's disease in stem-cell-derived human neurons transplanted into mouse brain
I Espuny-Camacho, AM Arranz, M Fiers, A Snellinx… - Neuron, 2017 - cell.com
Human pluripotent stem cells (PSCs) provide a unique entry to study species-specific
aspects of human disorders such as Alzheimer's disease (AD). However, in vitro culture of …
aspects of human disorders such as Alzheimer's disease (AD). However, in vitro culture of …
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease
The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer's disease
(AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ …
(AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ …