They react according to a succession of mono-or bimolecular processes to form at the end
one product that incorporates important portions and functionalities of the starting materials …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …

Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …

The electrochemical behavior of fac‐[Mn (pdbpy)(CO) 3Br](pdbpy= 4‐phenyl‐6‐(phenyl‐2, 6‐
diol)‐2, 2′‐bipyridine)(1) in acetonitrile under Ar, and its catalytic performances for CO2 …

Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …

DNA topoisomerases (topos) are essential enzymes that regulate the topological state of
DNA during cellular processes such as replication, transcription, recombination, and …

For the development of novel antitumor agents, we designed and synthesized 2, 6-diaryl-
substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of …

Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with
sodium salt of 3-hydroxy-1-(2-naphthyl) prop-2-en-1-one gives pyridin-2-one, pyridin-2 (1H) …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …