[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities
MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …
SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2
Y Lei, J Zhang, CR Schiavon, M He, L Chen… - Circulation …, 2021 - Am Heart Assoc
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the
binding of S protein (Spike glycoprotein) to ACE (angiotensinconverting enzyme) 2 in the …
binding of S protein (Spike glycoprotein) to ACE (angiotensinconverting enzyme) 2 in the …
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S)
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …
UbiBrowser 2.0: a comprehensive resource for proteome-wide known and predicted ubiquitin ligase/deubiquitinase–substrate interactions in eukaryotic species
X Wang, Y Li, M He, X Kong, P Jiang, X Liu… - Nucleic acids …, 2022 - academic.oup.com
As an important post-translational modification, ubiquitination mediates∼ 80% of protein
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling
A Balistrieri, A Makino, JXJ Yuan - Physiological reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …
The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases
A Hasanvand - Inflammopharmacology, 2022 - Springer
Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice
Targeting angiotensin-converting enzyme 2 (ACE2) represents a promising and effective
approach to combat not only the COVID-19 pandemic but also potential future pandemics …
approach to combat not only the COVID-19 pandemic but also potential future pandemics …
ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
CW Wang, HC Chuang, TH Tan - Journal of Biomedical Science, 2023 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-
angiotensin system, provides protection against several chronic diseases. Besides chronic …
angiotensin system, provides protection against several chronic diseases. Besides chronic …
COVID-19 in children: expressions of type I/II/III interferons, TRIM28, SETDB1, and endogenous retroviruses in mild and severe cases
PA Tovo, S Garazzino, V Dapra, G Pruccoli… - International journal of …, 2021 - mdpi.com
Children with the new coronavirus disease 2019 (COVID-19) have milder symptoms and a
better prognosis than adult patients. Several investigations assessed type I, II, and III …
better prognosis than adult patients. Several investigations assessed type I, II, and III …