Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …

The development and function of the central nervous system rely on the microtubule (MT)
and actin cytoskeletons and their respective effectors. Although the structural role of the …

Collapsin response mediator proteins (CRMPs), which consist of five homologous cytosolic
proteins, are one of the major phosphoproteins in the developing nervous system. The …

Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to
be established, and there is no way of predicting who will respond to therapy. This study …

The discovery and developmental processes of CNS drugs have been limited by the inability
of potential drug molecules to pass through the blood-brain barrier (BBB). This presents a …

Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including
mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative …

Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a
multi-layered signaling network in a time-and space-dependent manner. Dysregulation of …

Though the great success of paclitaxel, the variable response of patients to the drug limits its
clinical utility and the precise mechanisms underlying the variable response to paclitaxel …

Early life experience is closely related to depression caused by stress in adulthood. Early life
experience, including maternal separation (MS), has been shown to evoke stress sensitivity …

Early neurodevelopmental dysplasia or disorder is an important stimulus for depression, but
early stress can easily damage nerve development and lead to decreased neural plasticity …