Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny

H Chen, MBR Alves… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

New horizons in human sperm selection for assisted reproduction

B Nixon, JE Schjenken, ND Burke… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a commonly encountered pathology that is estimated to be a contributory
factor in approximately 50% of couples seeking recourse to assisted reproductive …

Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa

DA Skerrett-Byrne, AL Anderson, EG Bromfield… - Cell Reports, 2022 - cell.com
Spermatozoa acquire fertilization potential during passage through a highly specialized
region of the extratesticular ductal system known as the epididymis. In the absence of de …

Anatomical transcriptome atlas of the male mouse reproductive system during aging

Y Huang, X Li, X Sun, J Yao, F Gao, Z Wang… - Frontiers in Cell and …, 2022 - frontiersin.org
The elderly males undergo degenerative fertility and testicular endocrine function that
jeopardize the reproductive health and well-being. However, the mechanisms underlying …

Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice

N Trigg, JE Schjenken, JH Martin… - Proceedings of the …, 2024 - pnas.org
Forecasted increases in the prevalence and severity of extreme weather events
accompanying changes in climatic behavior pose potential risk to the reproductive capacity …

Proteomic analysis of koala (phascolarctos cinereus) spermatozoa and prostatic bodies

DA Skerrett‐Byrne, AL Anderson, L Hulse, C Wass… - …, 2021 - Wiley Online Library
The aims of this study were to investigate the proteome of koala spermatozoa and that of the
prostatic bodies with which they interact during ejaculation. For this purpose, spermatozoa …

Immortalized mouse caput epididymal epithelial (mECap18) cell line recapitulates the in‐vivo environment

JE Mulhall, NA Trigg, IR Bernstein, AL Anderson… - …, 2024 - Wiley Online Library
Residing between the testes and the vas deferens, the epididymis is a highly convoluted
tubule whose unique luminal microenvironment is crucial for the functional maturation of …

Advances in human reproductive biomarkers

A Mobed, B Abdi, S Masoumi, M Mikaeili… - Clinica Chimica …, 2024 - Elsevier
Reproductive biomarkers are important regulators in women, especially during pregnancy
and childbirth. Because of their essential role in women's health, the discovery and …

Single sperm vitrification with permeable cryoprotectant-free medium is more effective in patients with severe oligozoospermia and azoospermia

B Maleki, MA Khalili, L Gholizadeh, E Mangoli… - Cryobiology, 2022 - Elsevier
Testicular sperm extraction (TESE) is an invasive surgery for achieving the spermatozoa in
cases with azoospermia. In these patients, the number of retrieved spermatozoa is limited …

A novel role for milk fat globule‐EGF factor 8 protein (MFGE8) in the mediation of mouse sperm–extracellular vesicle interactions

NA Trigg, SJ Stanger, W Zhou, DA Skerrett‐Byrne… - …, 2021 - Wiley Online Library
Spermatozoa transition to functional maturity as they are conveyed through the epididymis, a
highly specialized region of the male excurrent duct system. Owing to their transcriptionally …