Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …

Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …

Haplodeficiency of the microglia gene TREM2 increases risk for late-onset Alzheimer's
disease (AD) but the mechanisms remain uncertain. To investigate this, we used high …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Aβ1–42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role
in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …

Amyloid refers to insoluble protein aggregates that are responsible for amyloid diseases but
are also implicated in important physiological functions (functional amyloids). The …

Control and analysis of protein aggregation is an increasing challenge to pharmaceutical
research and development. Due to the nature of protein interactions, protein aggregation …

Ordered protein aggregation in the brain is a hallmark of Alzheimer's disease and scrapie.
The disease-specific amyloid fibrils comprise primarily a single protein, amyloid β, in …

Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …

Extensive research causally links amyloid-β peptide (Aβ) to Alzheimer's disease, although
the pathologically relevant Aβ conformation remains unclear. Aβ spontaneously aggregates …