Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic
target of rapamycin) was activated and then up-regulated in injured axons, owing to local …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Critical functions of intra-axonally synthesized proteins are thought to depend on regulated
recruitment of mRNA from storage depots in axons. Here we show that axotomy of …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Neurons are the largest known cells, with complex and highly polarized morphologies. As
such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer …

Targeted delivery and precise release of toxins is a prospective strategy for the treatment of
triple-negative breast cancer (TNBC), yet the flexibility to incorporate both properties …

Localization and translation of mRNAs within different subcellular domains provides an
important mechanism to spatially and temporally introduce new proteins in polarized cells …

Essentially all cells contain a variety of spatially restricted regions that are important for
carrying out specialized functions. Often, these regions contain specialized transcriptomes …