Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour
immune response, but also interact intimately with the transformed cells to promote …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause
severe disease in humans with an immature or suppressed immune system. The outcome of …

Advances in biosensor technologies for in vitro diagnostics have the potential to transform
the practice of medicine. Despite considerable work in the biosensor field, there is still no …

Constitutive Notch activation is required for the proliferation of a subgroup of T-cell acute
lymphoblastic leukemia (T-ALL). Downstream pathways that transmit pro-oncogenic signals …

CD4+ CD25+ T regulatory (T reg) cells control immunologic tolerance to self-antigens and
play a role in suppressing antitumor immune responses, but the mechanism of suppression …

Abstract Introduction Basal-like carcinomas (BLCs) and human epidermal growth factor
receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that …

Mapping of protein signaling networks within tumors can identify new targets for therapy and
provide a means to stratify patients for individualized therapy. Despite advances in …

Multiple sclerosis is an inflammatory disease of the central nervous system that begins as a
relapsing-remitting disease (RRMS) and is followed by a progressive phase (SPMS). The …

Antibody arrays have valuable applications in cancer research. Many different antibody
array technologies have been developed, each with particular advantages, disadvantages …