Control principles of complex systems
YY Liu, AL Barabási - Reviews of Modern Physics, 2016 - APS
A reflection of our ultimate understanding of a complex system is our ability to control its
behavior. Typically, control has multiple prerequisites: it requires an accurate map of the …
behavior. Typically, control has multiple prerequisites: it requires an accurate map of the …
Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms
ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
Identification of small molecule activators of cryptochrome
Impairment of the circadian clock has been associated with numerous disorders, including
metabolic disease. Although small molecules that modulate clock function might offer …
metabolic disease. Although small molecules that modulate clock function might offer …
Evolution of circadian rhythms: from bacteria to human
The human body persists in its rhythm as per its initial time zone, and transition always occur
according to solar movements around the earth over 24 h. While traveling across different …
according to solar movements around the earth over 24 h. While traveling across different …
A mechanism for robust circadian timekeeping via stoichiometric balance
Circadian (∼ 24 h) timekeeping is essential for the lives of many organisms. To understand
the biochemical mechanisms of this timekeeping, we have developed a detailed …
the biochemical mechanisms of this timekeeping, we have developed a detailed …
Tuning the mammalian circadian clock: robust synergy of two loops
A Relógio, PO Westermark, T Wallach… - PLoS computational …, 2011 - journals.plos.org
The circadian clock is accountable for the regulation of internal rhythms in most living
organisms. It allows the anticipation of environmental changes during the day and a better …
organisms. It allows the anticipation of environmental changes during the day and a better …
[图书][B] The web of meaning: Integrating science and traditional wisdom to find our place in the universe
J Lent - 2021 - books.google.com
“A profound personal meditation on human existence... weaving together... historic and
contemporary thought on the deepest question of all: why are we here?”—Gabor Maté MD …
contemporary thought on the deepest question of all: why are we here?”—Gabor Maté MD …
[HTML][HTML] Dynamics and control at feedback vertex sets. II: A faithful monitor to determine the diversity of molecular activities in regulatory networks
A Mochizuki, B Fiedler, G Kurosawa, D Saito - Journal of theoretical biology, 2013 - Elsevier
Modern biology provides many networks describing regulations between many species of
molecules. It is widely believed that the dynamics of molecular activities based on such …
molecules. It is widely believed that the dynamics of molecular activities based on such …
At the interface of lifestyle, behavior, and circadian rhythms: metabolic implications
Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by
lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag …
lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag …
Functional observability and target state estimation in large-scale networks
The quantitative understanding and precise control of complex dynamical systems can only
be achieved by observing their internal states via measurement and/or estimation. In large …
be achieved by observing their internal states via measurement and/or estimation. In large …