[HTML][HTML] The crosstalk between DNA-damage responses and innate immunity
DNA damage is typically caused during cell growth by DNA replication stress or exposure to
endogenous or external toxins. The accumulation of damaged DNA causes genomic …
endogenous or external toxins. The accumulation of damaged DNA causes genomic …
When DNA-damage responses meet innate and adaptive immunity
J Tong, J Song, W Zhang, J Zhai, Q Guan… - Cellular and Molecular …, 2024 - Springer
When cells proliferate, stress on DNA replication or exposure to endogenous or external
insults frequently results in DNA damage. DNA-Damage Response (DDR) networks are …
insults frequently results in DNA damage. DNA-Damage Response (DDR) networks are …
Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis
Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell
dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed …
dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed …
TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation
AB Tufan, K Lazarow, M Kolesnichenko… - The EMBO …, 2022 - embopress.org
In a genome‐wide screening for components of the dsDNA‐break‐induced IKK‐NF‐κB
pathway, we identified scores of regulators, including tumor susceptibility gene TSG101 …
pathway, we identified scores of regulators, including tumor susceptibility gene TSG101 …
TIFAB regulates USP15-mediated p53 signaling during stressed and malignant hematopoiesis
TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in
myeloid malignancies with deletion of chromosome 5q. Employing a combination of …
myeloid malignancies with deletion of chromosome 5q. Employing a combination of …
Single cell transcriptomics of fibrotic lungs unveils aging-associated alterations in endothelial and epithelial cell regeneration
Lung regeneration deteriorates with aging leading to increased susceptibility to pathologic
conditions, including fibrosis. Here, we investigated bleomycin-induced lung injury …
conditions, including fibrosis. Here, we investigated bleomycin-induced lung injury …
CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis
Despite the emerging evidence on ferroptosis implicated in diverse pathologies, molecular
linkage between oxidative inducers and chromatin as epigenetic memory carrier for its …
linkage between oxidative inducers and chromatin as epigenetic memory carrier for its …
Cell-type-specific gene expression in developing mouse neocortex: intermediate progenitors implicated in axon development
Cerebral cortex projection neurons (PNs) are generated from intermediate progenitors (IPs),
which are in turn derived from radial glial progenitors (RGPs). To investigate developmental …
which are in turn derived from radial glial progenitors (RGPs). To investigate developmental …
[HTML][HTML] TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease
M Niederkorn, P Agarwal, DT Starczynowski - Experimental Hematology, 2020 - Elsevier
Highlights•FHA domain-containing proteins are critical gatekeepers of diverse signaling
pathways.•TIFA and TIFAB are critical FHA domain-containing proteins in immune-sensing …
pathways.•TIFA and TIFAB are critical FHA domain-containing proteins in immune-sensing …
The osteoprotective role of USP26 in coordinating bone formation and resorption
C Li, M Qiu, L Chang, J Qi, L Zhang, B Ryffel… - Cell Death & …, 2022 - nature.com
Bone homeostasis is maintained through a balance of bone formation by osteoblasts and
bone resorption by osteoclasts. Ubiquitin-specific proteases (USPs) are involved in …
bone resorption by osteoclasts. Ubiquitin-specific proteases (USPs) are involved in …