Prognosis and personalized treatment prediction in TP53-mutant hepatocellular carcinoma: an in silico strategy towards precision oncology

C Yang, X Huang, Y Li, J Chen, Y Lv… - Briefings in …, 2021 - academic.oup.com
TP53 mutation is one of the most common genetic changes in hepatocellular carcinoma
(HCC). It is of great clinical significance to tailor specialized prognostication approach and to …

Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma

GM Liu, HD Zeng, CY Zhang, JW Xu - Cancer cell international, 2019 - Springer
Background Hepatocellular carcinoma (HCC) remains a major challenge for public health
worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models …

A hypoxia-related signature for clinically predicting diagnosis, prognosis and immune microenvironment of hepatocellular carcinoma patients

B Zhang, B Tang, J Gao, J Li, L Kong, L Qin - Journal of Translational …, 2020 - Springer
Background Hypoxia plays an indispensable role in the development of hepatocellular
carcinoma (HCC). However, there are few studies on the application of hypoxia molecules in …

Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer

L Wang, C Qiao, L Cao, S Cai, X Ma, X Song… - Critical Reviews in …, 2022 - Elsevier
The transcription factors (TFs) of the HOX family play significant roles during early embryonic
development and cellular processes. They also play a key role in tumorigenesis as tumor …

[HTML][HTML] DNA methylation-driven genes for constructing diagnostic, prognostic, and recurrence models for hepatocellular carcinoma

J Long, P Chen, J Lin, Y Bai, X Yang, J Bian, Y Lin… - Theranostics, 2019 - ncbi.nlm.nih.gov
In this study, we performed a comprehensively analysis of gene expression and DNA
methylation data to establish diagnostic, prognostic, and recurrence models for …

Development and validation of a novel immune-related prognostic model in hepatocellular carcinoma

Z Wang, J Zhu, Y Liu, C Liu, W Wang, F Chen… - Journal of translational …, 2020 - Springer
Background Growing evidence has suggested that immune-related genes play crucial roles
in the development and progression of hepatocellular carcinoma (HCC). Nevertheless, the …

A novel ten-gene signature predicting prognosis in hepatocellular carcinoma

T Zhou, Z Cai, N Ma, W Xie, C Gao, M Huang… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) has a dismal long-term outcome. We aimed to construct a
multi-gene model for prognosis prediction to inform HCC management. The cancer-specific …

A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma

G Ouyang, B Yi, G Pan, X Chen - Cancer Cell International, 2020 - Springer
Background The prognosis of hepatocellular carcinoma (HCC) patients remains poor.
Identifying prognostic markers to stratify HCC patients might help to improve their outcomes …

Identification of crucial genes associated with immune cell infiltration in hepatocellular carcinoma by weighted gene co-expression network analysis

D Wang, J Liu, S Liu, W Li - Frontiers in genetics, 2020 - frontiersin.org
The dreadful prognosis of hepatocellular carcinoma (HCC) is primarily due to the low early
diagnosis rate, rapid progression, and high recurrence rate. Valuable prognostic biomarkers …

Whole‐genome sequencing identifies new candidate genes for nonobstructive azoospermia

A Malcher, T Stokowy, A Berman, M Olszewska… - …, 2022 - Wiley Online Library
Background Genetic causes that lead to spermatogenetic failure in patients with
nonobstructive azoospermia (NOA) have not been yet completely established. Objective To …