Selenium (Se) is an essential trace element of the utmost importance to human health. Its
deficiency induces various disorders. Se species can be absorbed by organisms and …

With the growing popularity of serine/threonine ligation (STL) and cysteine/penicillamine
ligation (CPL) in chemical protein synthesis, facile and general approaches for the …

Comprehensive Summary Expressed protein ligation (EPL) provides a powerful tool to
access large‐size proteins with precise structures. Existing methods for constructing the …

Selenoprotein F (SELENOF) might play an important role in maintaining human health since
an increasing number of studies have linked SELENOF deficiency to various pathologies …

The human selenoprotein H is the only selenocysteine-containing protein that is located in
the cell's nucleolus. In vivo studies have suggested that it plays some role in DNA binding …

Tyrosine sulfation is an important post-translational modification that enhances the inhibitory
activity of hirudin. Herein, we developed a facile synthetic strategy to afford the sulfated …

Native chemical ligation (NCL) has been playing an increasingly important role in chemical
protein synthesis (CPS). More efficient ligation methods that circumvent the requirement of a …

Herein, we report a semi-synthetic strategy affording a nitrophorin 2 (NP2) variant with a N,
N′-bis (2-pyridylmethyl) amine (Dpa) ligand as sidechain selectively installed at position …

Selenoproteins, the functional form of the essential trace element selenium, play a vital role
in maintaining redox homeostasis in humans. Selenocysteine (Sec), which constitutes the …