From tumour heterogeneity to advances in precision treatment of colorectal cancer
CJA Punt, M Koopman, L Vermeulen - Nature reviews Clinical oncology, 2017 - nature.com
In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …
[HTML][HTML] Management of colorectal cancer
S Stintzing - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Colorectal cancer is one of the most frequent solid tumors in the Western world. Treatment
options are dependent on the stage of the disease, the performance status of the patient …
options are dependent on the stage of the disease, the performance status of the patient …
Stromal contribution to the colorectal cancer transcriptome
Recent studies identified a poor-prognosis stem/serrated/mesenchymal (SSM)
transcriptional subtype of colorectal cancer (CRC). We noted that genes upregulated in this …
transcriptional subtype of colorectal cancer (CRC). We noted that genes upregulated in this …
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict.
Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype …
Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype …
Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value
Background Colon cancer (CC) pathological staging fails to accurately predict recurrence,
and to date, no gene expression signature has proven reliable for prognosis stratification in …
and to date, no gene expression signature has proven reliable for prognosis stratification in …
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial‐to‐mesenchymal transition
In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with
similar clinicopathological features can have differences in disease progression and …
similar clinicopathological features can have differences in disease progression and …
Clinical significance of four molecular subtypes of gastric cancer identified by the cancer genome atlas project
Abstract Purpose: The Cancer Genome Atlas (TCGA) project recently uncovered four
molecular subtypes of gastric cancer: Epstein–Barr virus (EBV), microsatellite instability …
molecular subtypes of gastric cancer: Epstein–Barr virus (EBV), microsatellite instability …
Novel genetic and epigenetic biomarkers of prognostic and predictive significance in stage II/III colorectal cancer
The therapeutic strategies of stage II/III colorectal cancer (CRC) patients after curative
surgery remain controversial. In the clinical decision-making process, oncologists need to …
surgery remain controversial. In the clinical decision-making process, oncologists need to …
The clinical relevance of gene expression based prognostic signatures in colorectal cancer
Colorectal cancer (CRC) is one of the most prevalent cancers, with more than one million
new cases every year. In the last few decades, several advancements in therapeutic and …
new cases every year. In the last few decades, several advancements in therapeutic and …
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
A Schlicker, G Beran, CM Chresta, G McWalter… - BMC medical …, 2012 - Springer
Background Colorectal cancer (CRC) is a heterogeneous and biologically poorly
understood disease. To tailor CRC treatment, it is essential to first model this heterogeneity …
understood disease. To tailor CRC treatment, it is essential to first model this heterogeneity …