Magnetic micro-macro biocatalysts applied to industrial bioprocesses
The use of magnetic biocatalysts is highly beneficial in bioprocesses technology, as it allows
their easy recovering and enhances biocatalyst lifetime. Thus, it simplifies operational …
their easy recovering and enhances biocatalyst lifetime. Thus, it simplifies operational …
Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues
SC Cosgrove, GJ Miller - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction Nucleoside analogues represent a cornerstone of achievement in drug
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …
Designing an Efficient Biocatalyst for the Phosphoribosylation of Antiviral Pyrazine-2-carboxamide Derivatives
EA Zayats, IV Fateev, YA Abramchik… - ACS …, 2024 - ACS Publications
The development of technologies for the efficient synthesis of innovative antiviral
compounds remains an important challenge for modern biotechnology, especially in the …
compounds remains an important challenge for modern biotechnology, especially in the …
New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases
Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …
Enzyme‐mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry
Molnupiravir (Lagevrio®) is an orally‐administered anti‐COVID‐19 agent. Due to the
urgency to meet the worldwide demand and the growing environmental concern, there is a …
urgency to meet the worldwide demand and the growing environmental concern, there is a …
Thermophilic nucleoside phosphorylases: Their properties, characteristics and applications
S Kamel, I Thiele, P Neubauer, A Wagner - Biochimica et Biophysica Acta …, 2020 - Elsevier
Nucleoside phosphorylases catalyze the reversible phosphorolysis of pyrimidine and purine
nucleosides in the presence of phosphate. They are valuable catalysts in the synthesis of …
nucleosides in the presence of phosphate. They are valuable catalysts in the synthesis of …
Structural and functional characterization of thermostable biocatalysts for the synthesis of 6-aminopurine nucleoside-5′-monophospate analogues
J Del Arco, E Pérez, H Naitow, Y Matsuura… - Bioresource …, 2019 - Elsevier
The present work describes the functional and structural characterization of adenine
phosphoribosyltransferase 2 from Thermus thermophilus HB8 (TtAPRT2). The combination …
phosphoribosyltransferase 2 from Thermus thermophilus HB8 (TtAPRT2). The combination …
Rational design of a thermostable 2′-deoxyribosyltransferase for nelarabine production by prediction of disulfide bond engineering sites
One of the major drawbacks of the industrial implementation of enzymatic processes is the
low operational stability of the enzymes under tough industrial conditions. In this respect, the …
low operational stability of the enzymes under tough industrial conditions. In this respect, the …
[HTML][HTML] Biotechnological applications of purine and pyrimidine deaminases
Deaminases, ubiquitous enzymes found in all living organisms from bacteria to humans,
serve diverse and crucial functions. Notably, purine and pyrimidine deaminases, while …
serve diverse and crucial functions. Notably, purine and pyrimidine deaminases, while …
Production of modified nucleosides in a continuous enzyme membrane reactor
Nucleoside analogues are important compounds for the treatment of viral infections or
cancers. While (chemo-) enzymatic synthesis is a valuable alternative to traditional chemical …
cancers. While (chemo-) enzymatic synthesis is a valuable alternative to traditional chemical …