Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

The thymus gland is a central lymphoid organ in which bone marrow-derived T cell
precursors undergo differentiation, eventually leading to migration of positively selected …

Infectious disease immunology has largely focused on the effector immune response,
changes in the blood and peripheral lymphoid organs of infected individuals, and vaccine …

Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …

Cell migration is crucial for intrathymic T-cell differentiation. Chemokines and extracellular
matrix proteins per se induce thymocyte migration, and recent data suggest a combinatorial …

Cell migration is crucial for thymocyte differentiation, and the cellular interactions involved
now begin to be unraveled, with chemokines, extracellular matrix (ECM) proteins, and their …

Trypanosoma cruzi, the causative agent of Chagas' disease, induces transient thymic
aplasia early after infection—a phenomenon that stills lacks a molecular explanation. The …

Pathophysiology of Chagas' disease is not completely defined, although innate and
adaptative immune responses are crucial. In acute infection some parasite antigens can …

Functional interactions between neuroendocrine and immune systems are mediated by
similar ligands and receptors, which establish a bi-directional communication that is relevant …

Extrathymic CD4+ CD8+ double-positive (DP) T cells are increased in some
pathophysiological conditions, including infectious diseases. In the murine model of Chagas …