Alzheimer's disease (AD) is a degenerative neurological disease in elderly individuals.
Subjective cognitive decline (SCD), mild cognitive impairment (MCI) and further …

The concept of the glymphatic system was proposed more than a decade ago as a
mechanism for interstitial fluid flow and waste removal in the central nervous system. The …

Interstitial fluid (ISF) refers to the fluid between the parenchymal cells and along the
perivascular spaces (PVS). ISF plays a crucial role in delivering nutrients and clearing waste …

The term free-water volume fraction (FWVF) refers to the signal fraction that could be found
as the cerebrospinal fluid of the brain, which has been demonstrated as a sensitive measure …

Introduction Free‐water (FW) imaging, a new analysis method for diffusion magnetic
resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated …

Late-life depression (LLD) is both common and disabling and doubles the risk of dementia
onset. Apathy might constitute an additional risk of cognitive decline but clear understanding …

In cerebral small vessel disease (CSVD), both white matter hyperintensities (WMH) of
presumed vascular origin and the normal-appearing white matter (NAWM) contain …

Background The correlations between genetic risk for Alzheimer's disease (AD) with
comprehensive brain regions at a regional scale are still not well understood. We aim to …

Several studies have shown white matter (WM) abnormalities in Alzheimer's disease (AD)
using diffusion tensor imaging (DTI). Nonetheless, robust characterization of WM changes …

It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …