Recent advances in DNA gyrase-targeted antimicrobial agents
Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …
United States alone, it is responsible for the death of more than 20,000 people each year …
Indole/isatin‐containing hybrids as potential antibacterial agents
F Song, Z Li, Y Bian, X Huo, J Fang… - Archiv der …, 2020 - Wiley Online Library
The emergence and worldwide spread of drug‐resistant bacteria have already posed a
serious threat to human life, creating the urgent need to develop potent and novel …
serious threat to human life, creating the urgent need to develop potent and novel …
Discovery of new Schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR/DNA gyrase …
A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …
Experimental and theoretical investigation for 6-Morpholinosulfonylquinoxalin-2 (1H)-one and its haydrazone derivate: Synthesis, characterization, tautomerization …
This work aimed to synthesize a safe antimicrobial agent based on dihydroquinoxalinedione
derivatives. The structure of the synthesized compounds was established based on different …
derivatives. The structure of the synthesized compounds was established based on different …
Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological …
YA Ammar, AA Farag, AM Ali, SA Hessein, AA Askar… - Bioorganic …, 2020 - Elsevier
Abstract A series of thiadiazino [5, 6-b] quinoxaline and thiazolo [4, 5-b] quinoxaline
derivatives was designed and synthetized from the reaction of 2, 3-dichloro-6 …
derivatives was designed and synthetized from the reaction of 2, 3-dichloro-6 …
One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA …
Abstract a series of 2-oxospiro [indoline-3, 4′-pyran] derivatives 4 and 7 were obtained in
good yield under mild conditions from the one-pot reaction of indole-2, 3-dione derivatives 1 …
good yield under mild conditions from the one-pot reaction of indole-2, 3-dione derivatives 1 …
Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors
A series of Schiff bases 3, 5, 7 and hydrazones 9 were achieved via reaction of 5-
(morpholinosulfonyl) indol-2, 3-dione (1) with appropriate amines and/or hydrazide …
(morpholinosulfonyl) indol-2, 3-dione (1) with appropriate amines and/or hydrazide …
New dual inhibitors of bacterial topoisomerases with broad-spectrum antibacterial activity and in vivo efficacy against vancomycin-intermediate Staphylococcus …
A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and
topoisomerase IV were developed. The resulting compounds show excellent broad …
topoisomerase IV were developed. The resulting compounds show excellent broad …
Antimicrobial activity and molecular docking screening of bioactive components of Antirrhinum majus (snapdragon) aerial parts
Abstract Background Antirrhinum majus (Snapdragon) is a perennial Mediterranean-native
plant that is commonly used for mass display. Few reports acknowledged the traditional use …
plant that is commonly used for mass display. Few reports acknowledged the traditional use …
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies
A series of coumarin derivatives were designed, synthesized, and evaluated for their
antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was …
antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was …