Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

Fasting exerts beneficial effects in mice and humans, including protection from
chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans …

The transition from a fasted to a fed state is associated with extensive transcriptional
remodeling in hepatocytes facilitated by hormonal-and nutritional-regulated transcription …

Inefficient physiological transitions are known to cause metabolic disorders. Therefore,
investigating mechanisms that constitute molecular switches in a central metabolic organ …

Understanding kinetic control of biological processes is as important as identifying
components that constitute pathways. Insulin signaling is central for almost all metazoans …

Metabolic alterations serve a significant role in the pathogenesis of kidney disease. Long
non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is a known regulator of …

Consumption of sugar-sweetened beverages (SSBs) have been linked to metabolic
dysfunction, obesity, diabetes and enhanced risk of cardiovascular diseases across all age …

The unprecedented access to annotated genomes now facilitates the investigation of the
molecular basis of epigenetic phenomena in phenotypically diverse animals. In this critical …

Intermediary metabolites and flux through various pathways have emerged as key
determinants of post-translational modifications. Independently, dynamic fluctuations in their …