Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard
to measure. To overcome this problem we have constructed new fluorescent indicators for …

Sephadex G-10 gel sieving chromatography, Jones-Dole viscosity B coefficients, and
solution neutron and X-ray diffraction are used to show that small ions of high charge density …

The 'EF-hand'Ca2+-binding motif plays an essential role in eukaryotic cellular signalling,
and the proteins containing this motif constitute a large and functionally diverse family. The …

Many extracellular signals, including light, biotic, and abiotic stress factors, elicit changes in
cellular Ca2+ concentration in plants (Trewavas and Knight, 1994; Bush, 1995; Braam et al …

The C2 domain is a Ca2+‐binding motif of approximately 130 residues in length originally
identified in the Ca2+‐dependent isoforms of protein kinase C. Single and multiple copies of …

In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter
release and in triggering alterations in neuronal function. Calmodulin has been widely …

CALCIUM entry through presynaptic calcium channels controls the release of
neurotransmitter1. It is not known whether the putative calcium sensor that triggers this rapid …

Metal ions are required for the growth of all life forms. 1-4 Currently, about half of all proteins
contain metal ions, 5 and most ribozymes cannot function without metal ion (s). 1-3, 6-11 …