While extensive research using animal models has improved the understanding of acute
kidney injury (AKI), this knowledge has not been translated into effective treatments. Many …

Hemorrhagic shock (HS) is a shock result of hypovolemic injury, in which the innate immune
response plays a central role in the pathophysiology ofthe severe complications and organ …

Traumatic hemorrhagic shock (THS) is a major cause of mortality and morbidity worldwide in
severely injured patients. Mesenchymal stem cells (MSCs) possess immunomodulatory …

Myocardial ischemia/reperfusion (I/R) elicits an acute inflammatory response involving
complement factors. Recently, we reported that myocardial necrosis was decreased in …

Acute kidney injury development after trauma, burn, or sepsis occurs frequently but remains
a scientific and clinical challenge. Whereas the pathophysiological focus has mainly been …

Patients in the intensive care unit (ICU) often straddle the divide between life and death.
Understanding the complex underlying pathomechanisms relevant to such situations may …

Background Around 10% of fractures lead to complications. With increasing fracture
incidences in recent years, this poses a serious burden on the healthcare system, with …

Hemorrhagic shock/resuscitation (HS/R) can lead to acute kidney injury, mainly manifested
as oxidative stress and inflammatory injury in the renal tubular epithelial cells, as well as …

Human thirty-eight-negative kinase-1 (TNK1) is implicated in cancer progression. The TNK1
ubiquitin-associated (UBA) domain binds polyubiquitin and plays a regulatory role in TNK1 …

Introduction: Imbalanced immune responses can lead to severe complications in multiple
trauma patients. MicroRNAs (miRNAs) are gene expression regulators involved in trauma …