The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

D Athanasiou, M Aguila, J Bellingham, W Li… - Progress in retinal and …, 2018 - Elsevier
Inherited mutations in the rod visual pigment, rhodopsin, cause the degenerative blinding
condition, retinitis pigmentosa (RP). Over 150 different mutations in rhodopsin have been …

Molecular basis for photoreceptor outer segment architecture

AFX Goldberg, OL Moritz, DS Williams - Progress in retinal and eye …, 2016 - Elsevier
To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Universal flow-induced orientational ordering of colloidal rods in planar shear and extensional flows: Dilute and semidilute concentrations

B Chun, HW Jung - Journal of Rheology, 2023 - pubs.aip.org
The design of flow processes to build a macroscopic bulk material from rod-shaped colloidal
particles has drawn considerable attention from researchers and engineers. Here, we …

Retinal thickness in children with anisohypermetropic amblyopia

T Nishi, T Ueda, T Hasegawa, K Miyata… - British Journal of …, 2015 - bjo.bmj.com
Purpose To determine the thickness of the fovea in eyes of children with anisohypermetropic
amblyopia, their fellow eyes and eyes of age-matched controls. Additionally, to assess the …

Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa

A Adekeye, M Haeri, E Solessio, BE Knox - PloS one, 2014 - journals.plos.org
The P23H mutation in rhodopsin (RhoP23H) is a prevalent cause of autosomal dominant
retinitis pigmentosa. We examined the role of the ER stress proteins, Chop and Ask1, in …

Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors

K Rose, N Chen, A Andreev, J Chen, VJ Kefalov… - Current Biology, 2024 - cell.com
Vision under dim light relies on primary cilia elaborated by rod photoreceptors in the retina.
This specialized sensory structure, called the rod outer segment (ROS), comprises hundreds …

Autosomal dominant retinitis pigmentosa with toxic gain of function: mechanisms and therapeutics

I Narasimhan, A Murali… - European Journal …, 2021 - journals.sagepub.com
Autosomal dominant retinitis pigmentosa is a form of retinitis pigmentosa, an inherited retinal
degenerative disorder characterized by progressive loss of photoreceptors eventually …

Regulation of Rhodopsin-eGFP Distribution in Transgenic Xenopus Rod Outer Segments by Light

M Haeri, PD Calvert, E Solessio, EN Pugh Jr, BE Knox - PloS one, 2013 - journals.plos.org
The rod outer segment (OS), comprised of tightly stacked disk membranes packed with
rhodopsin, is in a dynamic equilibrium governed by a diurnal rhythm with newly synthesized …

An Inducible Expression System to Measure Rhodopsin Transport in Transgenic Xenopus Rod Outer Segments

X Zhuo, M Haeri, E Solessio, BE Knox - PLoS One, 2013 - journals.plos.org
We developed an inducible transgene expression system in Xenopus rod photoreceptors.
Using a transgene containing mCherry fused to the carboxyl terminus of rhodopsin (Rho …

Quantum superposition in the retina: evidences and proposals

MR Khoshbin-e-Khoshnazar - NeuroQuantology, 2014 - search.proquest.com
The retina is a light-sensitive layer is structured at the plane outer segments of an array of
millions of individual nano-antennas. Apparently, the retina is one of the best known …